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A nivel europeo, la obesidad es definida como una enfermedad grave, crnica, recurrente y progresiva caracterizada por un exceso de adiposidad"

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Further, controlled clinical studies simulating NSW provide causal evidence that melatonin secretion diminishes rapidly upon night work exposure and remains suppressed with continued circadian disruption 183

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Importantly, when NF-B signaling was inhibited using a dominant-negative IB mutant, both cytokine levels and tissue damage were markedly reduced, confirming that ROS-mediated NF-B activation directly drives cytokine overproduction and multi-organ dysfunction in sepsis (Blackwell et al., 2000)